So, I had an issues with Report Builder not wanting to connect to the Database due to a certificate chain error in the prelogon handshake. I found this great post on TechNet Forums about the issue and it fixed it for me. There are detailed instructions on how to import the SCCM Database server’s certificate into your trusted root.
Start>run>mmc>file>add/remove snapins>certificate>Computer Account>Local Computer>Certificates>Personal>Certificates>Issued to: Name of server
Look at each cert. On the 3<sup style=”color:#1f497d;”>rd</sup> tab (Certification Path) it should say “ConfigMgr SQL Server Identification Certificate”. Export that cert.
Then on the machine running report builder, import the certificate to the local computer trusted root.